Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 26, 2000
Room T-530/530A HSC

Speaker: Michael Nolan
Topic: MS: Development of the Autoimmune Disease and Promising New Treatments


  1. Wucherpfennig, K. W., and Strominger, J. L. (1995) Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695-705.

  2. Allegretta, M., Nicklas, J. A., Sriram, S., and Albertini, R. J. (1990) T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247:718-721.

  3. Genain, C. P., Cannella, B., Hauser, S. L., and Raine, C. S. (1999) Identification of autoantibodies associated with myelin damage in multiple sclerosis [see comments]. Nat Med 5:170-175.

  4. Goverman, J., Woods, A., Larson, L., Weiner, L. P., Hood, L., and Zaller, D. M. (1993) Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551-560.


  1. Arnon, R. (1996) The development of Cop 1 (Copaxone), an innovative drug for the treatment of multiple sclerosis: personal reflections. Immunol Lett 50:1-15.

  2. Conlon, P., Oksenberg, J. R., Zhang, J., and Steinman, L. (1999) The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system. Neurobiol Dis 6:149-166.

  3. Steinman, L. (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299-302.

  4. Steinman, L. (1999) Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron 24:511-514.

1999-2000 Journal Club Schedule

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