Pharmacology 514:
Current Topics in Pharmacology
Journal Club




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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 16, 2000
Room T-530/530A HSC

Speaker: George Laszlo
Topic: Gephyrin, collybistin, molybdoenzymes, and other polypeptides that are hard too spel: the new complexity of the glycine receptor signaling machine


  1. Kneussel M, Brandstatter JH, Laube B, Stahl S, Muller U, Betz H, (1999). Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. J Neurosci, Nov 1;19(21):9289-97.

  2. Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR, (1999). Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science, Nov 13;282(5392):1321-4.

  3. Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr BA, Kirsch J, Betz H, Snyder SH, (1999). Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science 1999 May 14;284(5417):1161-4.

  4. Kins S, Betz H, Kirsch J,(2000). Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nat Neurosci, Jan;3(1):22-9.

  5. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron, May;20(5):895-904.

  6. Hall A (1998). Rho GTPases and the actin cytoskeleton. Science, Jan 23;279(5350):509-14.


  1. Kirsch J (1999). Assembly of signaling machinery at the postsynaptic membrane. Curr Opin Neurobiol, Jun;9(3):329-35.

  2. Fallon JR (2000). Building inhibitory synapses: exchange factors getting into the act? Nat Neurosci, Jan;3(1):5-6.


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