Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 23, 2000
Room T-530/530A HSC

Speaker: Victor Pineda
Topic: 'I must be drunk. I forgot what channel I'm on.' -- Ion channels as molecular targets of ethanol.

References:

  1. Covarrubias, M., et al., Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. J Biol Chem, 1995. 270(33): p. 19408-16.

  2. Kobayashi, T., et al., Ethanol opens G-protein-activated inwardly rectifying K+ channels. Nat Neurosci, 1999. 2(12): p. 1091-7.

  3. Lewohl, J.M., et al., G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci, 1999. 2(12): p. 1084-90.

  4. Mihic, S.J., et al., Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors [see comments]. Nature, 1997. 389(6649): p. 385-9.

  5. Ueno, S., et al., Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. Br J Pharmacol, 1999. 127(2): p. 377-82.

  6. Walter, H.J. and R.O. Messing, Regulation of neuronal voltage-gated calcium channels by ethanol. Neurochem Int, 1999. 35(2): p. 95-101.

  7. Wick, M.J., et al., Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci U S A, 1998. 95(11): p. 6504-9.

  8. Narahashi, T., et al., Neuronal nicotinic acetylcholine receptors: a new target site of ethanol. Neurochem Int, 1999. 35(2): p. 131-41.

  9. Dascal, N., Signalling via the G protein-activated K+ channels. Cell Signal, 1997. 9(8): p. 551-73.

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