Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, March 1, 2000
Room T-530/530A HSC

Speaker: Joe Beavo
Topic: Sense and antisense working together: the case for RNAi


  1. ***RNA interference: genetic wand and genetic watchdog. Bosher JM, Labouesse M Nat Cell Biol 2000 Feb;2(2):E31-E (this is a review and commentary on the following paper)

  2. ***Specific interference with gene function by double-stranded RNA in early mouse development. Wianny F, Zernicka-Goetz M Nat Cell Biol 2000 Feb;2(2):70-75

  3. ***Targeted mRNA degradation by double-stranded RNA in vitro Thomas Tuschl, Phillip D. Zamore, Ruth Lehmann, David P. Bartel, and Phillip A. Sharp GENES & DEVELOPMENT 13:31913197 1999

  4. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei Hua, N

  5. Ngo, Christian Tschudi, Keith Gull, and Elizabetta Ullu Proc. Natl. Acad. Sci. USA 95:1468714692, 1998

  6. RNA Interference Can Target Pre-mRNA: Consequences for Gene Expression in a Caenorhabditis elegans Operon Julia M. Bosher, Pascale Dufourcq,1 Satis Sookhareea and Michel Labouesse Genetics 153: 12451256 (November 1999)

  7. DoubleStranded RNA Induces Specific Developmental Defects in Zebrafish Embryos Anna Wargelius, Stle Ellingsen, and Anders Fjose Biochemical and Biophysical Research Communications 263, 156161 (1999)

  8. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans Mary K Montgomery, Siaun Xu and Andre W. Fire Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1550215507, December 1998

  9. Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonicsomatic muscle formation Leonie Misquitta and Bruce M Paterson Proc. Natl. Acad. Sci. USA 96:14511456, Feb 1999


  1. RNAi and double-strand RNA Phillip A. Sharp GENES & DEVELOPMENT 13:139141


  1. Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes Madhur Kumar, and Gordon G Carmichael Microbiol and Molec Biol Reviews, . 62:14151434 1998 (Note: This is a general recent review of dsRNA effects in cells. Not on RNAi)

1999-2000 Journal Club Schedule

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