Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, March 29, 2000
Room T-530/530A HSC

Speaker: Jennifer Glick
Topic: Peripheral Effects of Leptin


  1. Faggioni,R., Jones-Carson, J., Reed, D.A., Dinarello, C.A., Reingold, K.R., Grunfeld, C., and Fantuzzi, G. (2000) Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor alpha and IL-18. PNAS 97:2367-2372.

  2. Loffreda, S., Yang, S.Q., Lin, H.Z., Karp, C.L., Brengman, M.L., Wang, D.J., Klein, A.S., Bulkley, G.B., Bao, C., Noble, P.W., Lane, M.D., and Diehl, A.M. (1998) Leptin regulates proinflammatory immune responses. FASEB J. 12:57-65.

  3. Lord, G.M., Matarese, G., Howard, J.K., Baker, R.J., Bloom, S.R. and Lechler, R.I., (1998) Leptin Modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897-901.

  4. Sierra-Honigmann, M.R., Nath, A.K., Murakami, C., Garcia-Cardena, G, Papapetropoulos, A., Sessa, W.C., Madge, L.A., Schechner, J.S., Schwabb, M.B., Polverini, P.J., and Flores-Riveros, J.R. (1998) Biological action of leptin as an angiogenic factor. Science 281:1683-1686.

  5. Yang, S.Q., Lin, H.Z., Lane, M.D., Clemens, M., and Diehl, A.M. (1997) Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis. PNAS 94:2557-2562.

  6. Gainsford, T., Willson, T.A., Metcalf, D., Handman, E., McFarlane, C., Ng, A., Nicola, N.A., Alexander, W.S., and Hilton, D.J. (1996) Leptin can induce proliferation, differentiation, and functional activation of hemopoeitic cells. PNAS 93:14565-14568.

  7. Takahashi, N., Waelput, W., and Guisez, Y. (1999) Leptin is an endogenous protective protein against toxicity exerted by tumor necrosis factor. J. Exp. Med. 189:207-212.


  1. Dieguez, C. and Casanueva, F.F. (1999) Neuroendocrine regulation and actions of leptin. Frontiers in Neuroendocrinology. 20:317-363.

  2. Elmquist, J.K., Elias, C.F., and Saper, C.B. (1999) From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:221-232.


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