Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 12, 2000
Room T-530/530A HSC

Speaker: Traci Hilton
Topic: Quality Control in the Endoplasmic Reticulum: Recognition of Misfolded Proteins

References

  1. Gillece, P., Luz, J., Lennarz, W., de la Cruz, F., and Romisch, K. (1999) Export of a Cysteine-free Misfolded Secretory Protein from the Endoplasmic Reticulum for Degradation that Requires Interaction with Protein Disulfide Isomerase. J. of Cell Biol. 147: 1443-1456.

  2. Brodsky, J., Werner, E., Dubas, M., Goeckeler, J., Kruze, K., and McCracken, A. (1999) The Requirement for Molecular Chaperones during the Endoplasmic Reticulum-associated Protein Degradation Demonstrates that Protein Export and Import are Mechanistically Distinct. JBC 274: 3453-3460.

  3. Pilon, M., Schekman, R., and Romisch, K. (1997) Sec61p Mediates Export of a Misfolded Secretory Protein from the Endoplasmic Reticulum to the Cytosol for Degradation. EMBO 16: 4540-4548.

  4. Wilkinson, B., Tyson, J., Reid, R., and Stirling C. (2000) Distinct Domains within Yeast Sec61p Involved in Post-translational Translocation and Protein Dislocation. JBC 275: 521-529.

  5. Plemper, R., Bordallo, J., Deak, P., Taxis, C., Hitt, R., and Wolf, D. (1999) Genetic Interaction of Hrd3p and Der3p/Hrd1p with Sec61p Suggest a Retro-translocation Complex Mediating Protein Transport for ER Degradation. J. of Cell Science 112: 4123-4134.

  6. Wesche, J., Rapak, A., and Olsnes, S. (1999) Dependence of Ricin Toxicity on Translocation of the Toxin A-chain from the Endoplasmic Reticulum to the Cytosol. JBC 274: 34443-34449.

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