Pharmacology 514:
Current Topics in Pharmacology
Journal Club




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JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 19, 2000
Room T-530/530A HSC

Speaker: Dr. Edith Wang
Topic: Reeling CASK, a membrane associated protein, into the nucleus.


  1. Hata Y, Butz S, Sudhof TC. 1996. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J. Neurosci., 16(8):2488-94.

  2. Hsueh YP, Yang FC, Kharazia V, Naisbitt S, Cohen AR, Weinberg RJ, Sheng M. 1998. Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J. Cell Biol.,142(1):139-51.

  3. Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM. 1998. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J. Cell Biol., 142(1):129-38.

  4. Butz S, Okamoto M, Sudhof TC. 1998. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell, 94(6):773-82.

  5. Kaech SM, Whitfield CW, Kim SK. 1998. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell, 94(6):761-71.

  6. Hsueh YP, Wang TF, Yang FC, Sheng M. 2000. Nuclear translocation and transcription regulation by the membrane-guanylate kinase CASK/LIN-2. Nature, 404 (6775):298-302.


  1. Craven SE, Bredt DS. 1998. PDZ proteins organize synaptic signaling pathways. Cell, 93:495-498.

  2. Bredt D. 1998. Sorting out genes that regulate epithelial and neuronal polarity. Cell, 94:691-694.


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