Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 26, 2000
Room T-530/530A HSC

Speaker: Dr. Todd Scheuer
Topic: Go or Nogo: Inhibition of Axon Regeneration by CNS Myelin.


  1. Chen, M.S., Huber, A.B., van der Haar, M.E., Frank, M., Schnell, L., Spillmann, A.A., Christ, F., and Schwab, M.E. (2000). Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434-439.

  2. GrandPre, T., Nakamura, F., Vartanian, T., and Strittmatter, S.M. (2000). Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439-444.

  3. Prinjha, R., Moore, S.E., Vinson, M., Blake, S., Morrow, R., Christie, G., Michalovich, D., Simmons, D.L., and Walsh, F.S. (2000). Inhibitor of neurite outgrowth in humans. Nature 403, 383-384.

  4. Davies, S.J., Goucher, D.R., Doller, C., and Silver, J. (1999). Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19, 5810-5822.

  5. Huang, D.W., McKerracher, L., Braun, P.E., and David, S. (1999). A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 24, 639-647.

  6. Spillmann, A.A., Bandtlow, C.E., Lottspeich, F., Keller, F., and Schwab, M.E. (1998). Identification and characterization of a bovine neurite growth inhibitor (bNI-220). J Biol Chem 273, 19283-19293.

  7. Davies, S.J., Fitch, M.T., Memberg, S.P., Hall, A.K., Raisman, G., and Silver, J. (1997). Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390, 680-683.

  8. Li, M., Shibata, A., Li, C., Braun, P.E., McKerracher, L., Roder, J., Kater, S.B., and David, S. (1996). Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J Neurosci Res 46, 404-414.

  9. Schnell, L. and Schwab, M.E. (1990). Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343, 269-272.

  10. Schwab, M.E. and Caroni, P. (1988). Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J Neurosci 8, 2381-2393.

  11. David, S. and Aguayo, A.J. (1981). Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 214, 931-933.


  1. Tessier-Lavigne, M. and Goodman, C.S. (2000). Perspectives: neurobiology. Regeneration in the Nogo zone. Science 287, 813-814.

  2. Goldberg, J.L. and Barres, B.A. (2000). Nogo in nerve regeneration. Nature 403, 369-370.

  3. Goldberg, J.L. and Barres, B.A. (2000). The relationship between neuronal survival and regeneration. Ann Rev Neurosci 23, 579-612.


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