Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 5, 2000
Room T-530/530A HSC

Speaker: Margaret Allen
Topic: Homocysteine Thiolactone Hydrolase: The missing link in the homocysteine model of atherosclerosis?

References:

  1. Jakubowski, H. Calcium-dependent Human Serum Homocysteine Thiolactone Hydrolase: A protective mechanism against protein N-homocysteinylation. J. Biol. Chem. 275(6):3957-3962, 2000.

  2. Jakubowski, H. Homocysteine Thiolactone: Metabolic Origin and Protein Homocysteinylation in Humans. J. Nutr. 130:377S-381S, 2000.

  3. Temple, M.E., A.B. Luzier and D.J. Kazierad. Homocysteine as a Risk Factor for Atherosclerosis. Ann. Pharmacotherapy 34:57-65, 2000.

  4. McDowell, I.F.W. and D.Lang. Homocysteine and Endothelial Dysfunction: a Link with Cardiovascular Disease. J. Nutr. 130: 369S-372S, 2000.

  5. Vermeulen, E.G. et al. Effect of homocysteine-lowering treatment with folic acid plus viatmin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet 355(9203):517-522, 2000.

  6. Stone, D. H., P. McCaron and G.D. Smith. Similarities in the epidemiology of neural tube defects and coronary heart disease: is homocysteine the missing link? J. epidemiol Community Health 53(12):789-793, 1999.

  7. Rosenquist, T.H., S.A. Ratashak, and J. Selhub. Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc. Natl. Acad. Sci, USA 93:15227-15232, 1996.

  8. Sanghera, D.K., C.E. Aston, N. Saha, and M.I. Kamboh. DNA Polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Am. J. Hum. Genet. 62:36-44, 1998.

  9. Heineck, J.W. and A.J. Lusis. Paraoxonase-gene polymorphisms associated with coronary heart disease: support to the oxidative damage hypothesis? Am. J. Hum. Genet. 62:20-24, 1998.

  10. Shih, D.M. et al. Mice lacking serum paraoxonase are susceptible to organophospahte toxicity and atherosclerosis. Nature 394:284-287, 1998

General Reading:

  1. McCully, K.S. The Homocysteine Revolution Keats Publishing, Inc., New Canaan, CN 1997


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