Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 31, 2000
Room T-530/530A HSC

Speaker: Natalie Glavas
Topic: Identification of novel viral targets for treatment of HIV-1 infection.


  1. Sei, S., Yang, Q-E., O'Neill, D., Yoshimura, K., Nagashima, K. and Mitsuya, H. 2000. Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain. J. Virol. 74; 4621-4633.

  2. Bour, S., Perrin, C. and Strebel, K. 1999. Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity. J. Biol. Chem. 274; 33800-33806.

  3. Craig, H.M., Pandori, M.W. and Guatelli, J.C. 1998. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc. Natl. Acad. Sci. 95; 11229-11234.

  4. Akari, H., Arold, S., Fukumori, T., Okazaki, T., Strebel, K. and Adachi, A. 2000. Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation. J. Virol. 74; 2907-2912.

  5. Ayyavoo, V., Kudchodkar, S., Ramanathan, M.P., Le, P., Muthumani, K., Megalai, N.M., Dentchev, T., Santiago-Barrios, L., Mrinalini, C. and Weiner, D.B. 2000. Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes. AIDS. 14; 1-9.

  6. Mariani, R., Kirchhoff, F., Greenough, T.C., Sullivan, J.L., Desrosiers, R.C. and Skowronski, J. 1996. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J. Virol. 70; 7752-7764.

  7. Okamoto, H., Cujec, T.P., Peterlin, M. and Okamoto, T. 2000. HIV-1 replication is inhibited by a pseudo-substrate peptide that blocks tat transactivation. Virology 270; 337-344.


  1. Frankel, A.D. and Young, J.A.T. 1998. HIV-1: Fifteen proteins and an RNA. Annu. Rev. Biochem. 67; 1-25.

  2. Tantillo, C., DIng, J., Jacobo-Molina, A., Nanni, R.G., Boyer, P.L., Hughes, S.H., Pauwels, R., Andries, K., Janssen, P.A.J. and Arnold, E. 1994. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. J. Mol. Biol. 243; 369-387.

  3. Ridky, T. and Leis, J. 1995. Development of drug resistance to HIV-1 protease inhibitors. J. Biol. Chem. 270; 29621-29623.


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