Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 3, 2000
Room T-530/530A HSC

Speaker: Dr. Neil Nathanson
Topic: ReelinŐ in the signal transduction pathway for cortical development: a little Dab is enough to make you go Ape-O.

References

  1. D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995 Apr 20;374(6524):719-23.

  2. Hirotsune S, Takahara T, Sasaki N, Hirose K, Yoshiki A, Ohashi T, Kusakabe M, Murakami Y, Muramatsu M, Watanabe S, et al. The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Nat Genet. 1995 May;10(1):77-83.

  3. D'Arcangelo G, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Curran T. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci. 1997 Jan 1;17(1):23-31.

  4. Yoneshima H, Nagata E, Matsumoto M, Yamada M, Nakajima K, Miyata T, Ogawa M, Mikoshiba K. A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin. Neurosci Res. 1997 Nov;29(3):217-23.

  5. Howell BW, Gertler FB, Cooper JA. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J. 1997 Jan 2;16(1):121-32.

  6. Ware ML, Fox JW, Gonzalez JL, Davis NM, Lambert de Rouvroit C, Russo CJ, Chua SC Jr, Goffinet AM, Walsh CA. Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse. Neuron. 1997 Aug;19(2):239-49.

  7. Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell BW, Cooper JA, Goldowitz D, Curran T. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 1997 Oct 16;389(6652):730-3.

  8. Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 1998 Sep;125(18):3719-29.

  9. Borrell V, Del Rio JA, Alcantara S, Derer M, Martinez A, D'Arcangelo G, Nakajima K, Mikoshiba K, Derer P, Curran T, Soriano E. Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections. J Neurosci. 1999 Feb 15;19(4):1345-58.

  10. Howell BW, Herrick TM, Cooper JA. Reelin-induced tryosine phosphorylation of disabled 1 during neuronal positioning. Genes Dev. 1999 Mar 15;13(6):643-8.

  11. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, Hammer RE, Richardson JA, Herz J. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999 Jun 11;97(6):689-701.

  12. Senzaki K, Ogawa M, Yagi T. Proteins of the CNR family are multiple receptors for Reelin. Cell. 1999 Dec 10;99(6):635-47.

Reviews:

  1. Rice DS, Curran T. Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev. 1999 Nov 1;13(21):2758-73.

  2. Gilmore EC, Herrup K. Cortical development: receiving reelin. Curr Biol. 2000 Feb 24;10(4):R162-6.

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