Current Topics in Pharmacology
12:30 PM, Wednesday, October 11, 2000
Room T-473 HSC
Speaker: Katie Day
Topic: Sexual Repression: does methylation kill the Mojo??
DeChiara, TM, Robertson, EJ, Efstratiadis, A (1991) Parental imprinting of the mouse insulin-like Growth Factor II Gene. Cell 64: 849-59.
Li, E, Bestor, TH, Jaenisch, R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-26.
Li, E, Beard, C, Jaenisch, R (1993) Role for DNA methylation in genomic imprinting. Nature 366: 362-65.
Leighton, PA, Saam, JR, Ingram, RS, Stewart, CL, Tilghman, SM (1995) An enhancer deletion affects both H19 and Igf2 expression. Genes and Development 9: 2079-89.
Leighton, PA, Ingram, RS, Eggenschwiler, J, Efstratiadis, A, Tilghman, SM (1995) Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375: 34-39.
Tremblay, KD, Duran, KL, Bartolomei, MS (1997) A 5Í 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Molecular and Cellular Biology 17(8): 4322-29.
Jones, BK, Levorse, JM, Tilghman, SM (1998) Igf2 imprinting does not require its own DNA methylation or H19 RNA. Genes and Development 12: 2200-07.
Thorvaldesn, JL, Duran, KL, Bartolomei, MS (1998) Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes and Development 12: 3693-3702.
Hark, AT, Schoenherr, CJ, Katz, DJ, Ingram, RS, Levorse, JM, Tilghman, SM (2000) CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405: 486-89.
Bell, AC, Felsenfeld, G (2000) Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405: 482-85.
Kandrdui, C, Pant, V, Loukinov, D, Pugacheva, E, Qi, C-F, Wolffe, A, Ohlsson, R, Lobanenkov, VV (2000) Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin specific and methylation-sensitive. Current Biology 10: 853.
1. Bartolomei, MS, Tilghman, SM (1997) Genomic imprinting in mammals. Annu. Rev. Genet. 31: 493-525.
2000-2001 Journal Club Schedule