Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 18, 2000
Room T-473 HSC

Speaker: Cindy Reiner
Topic: Cash in on ATM signalling


  1. Taylor, A.M.R., Harnden, D.G., Arlett, C.F., Hardourt, S.A., Lehmann, A.R., Stevens, S., Bridges, B.A. (1975) Ataxia-telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 4: 427-429.

  2. Kastan, M.B., Zhan, Q., el-Deiry, W.S., Carrier, F., Jacks, T., Walsh, W.V., Plunkett, B.S., Vogelstein, B., Fornace, A.J., Jr. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.

  3. Zhang, N., Chen, P., Khanna, K.K., Scott, S., Gatei, M., Kozlov, S., Watters, D., Spring, K, Yen, T., Lavin, M.F. (1997) Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasai cellular phenotype. Proc. Natl. Acad. Sci. USA 94: 8021-8026.

  4. Siliciano, J.D., Canman, C.E., Taya, Y., Sakaguchi, K., Appella, E., Kastan, M.B. (1997) DNA damage induces phosphorylation of the amino terminus of p53. Genes and Development 11: 3471-3481.

  5. Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C.W., Chessa, L., Smorodinsky, N.I., Prives, C., Reiss, Y., Shiloh, Y., Ziv, Y. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 1674-1677.

  6. Canman, C.E., Lim, D., Cimprich, K., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M., Siliciano, J. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679.

  7. Matsuoka, S., Huang, M., Elledge, S. (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1897.

  8. Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A., Ruland, J., Yoshida, H., Liu, D., Elledge, S., Mak, T. (2000) DNA damage induced activation of p53 by the checkpoint kinase Chk2. Science 287: 1824-1827.

  9. Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., Elledge, S. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. USA 97: 10389-10394.

  10. Melchionna, R., Chen, X., Blasina, A., McGowan, C. (2000) Threonine 68 is required for radiation induced phosphorylation and activation of Cds1. Nat. Cel. Biol. 2: 762-765.

  1. 1. Lavin, M., Khanna, K.K. (1999) Review: ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. Int. J. Rad. Biol. 75: 1201-1214.

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