Pharmacology 514:
Current Topics in Pharmacology
Journal Club




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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 25, 2000
Room T-473 HSC

Speaker: Danielle Ippolito
Topic: Making the Silence Painful: Using LTP to define a role for silent glutamatergic synapses in nociception


I. Characterization of silent synapses

  1. Liao, D., Hessler, N.A., and Malinow, R. (1995). Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375: 400404.

  2. Nusser, Z., Lujan, R., Laube, G., Robberts, J.D.B., Molnar, E., Somogyi, P. (1998). Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21: 545-559.

  3. Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R (1999). Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284: 1811-1816.

  4. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow (2000). Driving AMPA receptors into the synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287: 2262-2267.

  5. Petralia, R.S., Esteban, J.A., Wang, Y.-X., Partridge, J.G., Zhao, H.-M., Wenhold, R.J., and Malinow, R. (1999). Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nature Neuroscience 2(1): 31-36.

  6. Choi, S., Klingauf, J., and Tsien, R.W. (2000). Postfusional regulation of cleft glutamate concentration during LTP at "silent synapses." Nature Neuroscience 3(4): 330-6.

II. A role for silent synapses in nociception
  1. Bardoni, R., Magherini, P.C., and MacDermott, A. (1998). NMDA EPSCs at glutamatergic synapses in the spinal cord dorsal horn in the postnatal rat. The Journal of Neuroscience 18(16): 6558-6567.

  2. Li, P., and Zhuo, M. (1998). Silent glutamatergic synpses and nociception in mammalian spinal cord. Nature 393: 695-698.

  3. Li, P., Kerchner, G.A., Sala, C., Wei, F., Huettner, J.E., Sheng, M., and Zhou, M. (1999). AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nature Neuroscience 2(11): 972-977.

  4. Baba, H., Doubell, T.P., Moore, K.A., and Woolf, C.J. (2000). Silent NMDA receptor-mediated synapses are developmentally regulated in the dorsal horn of the rat spinal cord. Journal of Neurophysiology 83: 955-962.

III. Reviews:
  1. Isaac, T.R., J., Nicoll, R.A., and Malenka, R.C. (1999). Silent glutamatergic synapses in the mammalian brain. Canadian Journal of Physiology and Pharmacology 77: 735-737.

  2. Kerchner, G.A., Li, P., and Zhuo, M. (1999). Speaking out of turn: A role for silent synapses in pain. IUBMB Life 48: 251-256.

  3. Malenka, R.C., and Nicoll, R.A. (1999). Long term potentiation-A decade of progress? Science 285: 1870-1874.

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