Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 4, 2000
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Stan McKnight
Topic: A CRE-LOX Assault on the Insulin Receptor

References:

  1. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR. (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289(5487):2122-5.

  2. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6(1):87-97.

  3. Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI. (2000) Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest 105(12):1791-7.

  4. Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ, Kahn CR. (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2(5):559-69.

  5. Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96(3):329-39.

  6. Joshi RL, Lamothe B, Cordonnier N, Mesbah K, Monthioux E, Jami J, Bucchini D. (1996) Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J 15(7):1542-7.

  7. Takahashi Y, Kadowaki H, Momomura K, Fukushima Y, Orban T, Okai T, Taketani Y, Akanuma Y, Yazaki Y, Kadowaki T. (1997) A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism. Diabetologia 40(4):412-20.

Reviews:

  1. Schwartz, MW. (2000) Staying slim with insulin in mind. Science 289:2066.

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