Pharmacology 514:
Current Topics in Pharmacology
Journal Club

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 22, 2000
Room T-473 HSC

Speaker: Lisa Walter
Topic: What an ICE idea: Caspase inhibition as a potential treatment of neurodegenerative disorders

References:

1. Ona VO et al. (1999) Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399: 263-267.

2. Chen M et al. (2000) Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nature Medicine 6: 797-801.

3. Li M et al. (2000) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288: 335-339.

4. Klevenyi et al. (1999) Transgenic mice expressing a dominant negative mutant interleukin-1B converting enzyme show resistance to MPTP neurotoxicity. NeuroReport 10: 635-638.

5. Hartmann et al. (2000) Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. PNAS 97: 2875-2880.

6. Gervais et al. (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 97: 395-406.

7. Li M et al. (2000) Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Neuroscience 99: 333-342.

1. Nicholson DW. (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407: 810-816.

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