Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 8, 2000
Room T-473 HSC

Speaker: Kavita Shah
Topic: An Evolutionary and Functional Rationale for Hormonal Regulation of Osteoporosis

Reports:

  1. Kong Y, Yoshida H, Sarosi I, Tan H, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteclastogenesis, lymphocyte development, and lymph-node organogenesis. Nature 1999 Jan 28; 397: 315-323.

  2. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Lee DR, Amgen EST Program, Boyle WJ. Osteoprotegrin: a novel secreted protein involved in the regulation of bone density. Cell 1997 Apr 18; 89: 309-319.

  3. Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998 May 1; 12(9): 1260-8.

  4. Min H, Morony S, Sarosi I, Dunstan CR, Capparelli C, Scully S, Van G, Kaufman S, Kostenuik PJ, Lacey DL, Boyle JB, Simonet WS. Osteoprotegrin reverses osteoporosis by inhibiting endosteal osteoclasts and preventing vascular calcification by blocking a process resembling osteoclastogenesis. J Exp Med 2000 Aug 21; 192(4): 463-474.

  5. Kimble RB, Srivastava S, Ross FP, Matayoshi A, Pacifici R. Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem 1996 Nov 15; 271(46): 28890-7.

  6. Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med 1996 Oct; 2(10): 1132-6.

  7. Lee SK, Lorenzo JA. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology 1999 Aug; 140(8): 3552-61.

  8. Fata JE, Kong Y, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The Osteclast Differentiation Factor osteprotegrin ligand is essential for mammary gland development. Cell 2000 Sept 29; 103: 41-50.

References:
  1. Riggs BL, Melton LJ. 1995 Osteoporosis: Etiology, Diagnosis, and Management, ed 2. Lippincott-Raven Publishers, Philadelphia, PA.

  2. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000 Sept 1; 289: 1504-1508.

  3. Suda T, Takahashi N, Udagawa N, Jimi E, Gillepsie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. End Rev 1999; 20(3): 345-357.

  4. Spelsberg TC, Subramaniam M, Riggs BL, Khosla S. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol End 1999; 13(6): 819-828.


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