Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 10, 2001
Room T-473 HSC

Speaker: Jeremy Celver
Topic: A toll for the innate immune system: Immune cell activation by CpG DNA

References:

  1. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 2000 Dec 7;408(6813): 740-5.

  2. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995 Apr 6;374(6522): 546-9.

  3. Krieg AM, Wu T, Weeratna R, Efler SM, Love-Homan L, Yang L, Yi AK, Short D, Davis HL. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci USA 1998 Oct 13;95(21): 12631-6.

  4. Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H. Immune Cell Activation by Bacterial CpG-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (TRAF)6. J Exp Med 2000 Aug 21;192(4): 595-600.

  5. Tapping RI, Akashi S, Miyake K, Godowski PJ, Tobias PS. Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for escherichia and salmonella lipopolysaccharides. J Immunol 2000 Nov 15;165(10): 5780-7.

  6. Schnare M, Holtdagger AC, Takeda K, Akira S, Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol 2000 Sep 21;10(18): 1139-42.

Reviews:
  1. Daun JM, Fenton MJ.Related ArticlesInterleukin-1/Toll receptor family members: receptor structure and signal transduction pathways. J Interferon Cytokine Res 2000 Oct;20(10): 843-55.

  2. Heeg K, Sparwasser T, Lipford GB, Hacker H, Zimmermann S, Wagner H Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis 1998 Jul;17(7): 464-9.

  3. Krieg AM. Immune effects and mechanisms of action of CpG motifs. Vaccine 2000 Nov 8;19(6): 618-22.


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