Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 17, 2001
Room T-473 HSC

Speaker: Scott Auerbach
Topic: The Role of Nuclear Receptors FXR and LXR in Cholesterol Homeostasis


  1. Goodwin, B., Jones, S.A., Price, R.R., Watson, M.A., McKee, D.D., Moore, L.B., Galardi, C., Wilson, J.G., Lewis, M.C., Roth, M.E., Maloney, P.R., Willson, T.M., and Kliewer, S.A. (2000). A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis [In Process Citation]. Mol. Cell 6, 517-526.

  2. Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.M., Hammer, R.E., and Mangelsdorf, D.J. (1998). Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93, 693-704.

  3. Repa, J.J., Turley, S.D., Lobaccaro, J.A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R.A., Dietschy, J.M., and Mangelsdorf, D.J. (2000). Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers [see comments]. Science 289, 1524-1529.

  4. Sinal, C.J., Tohkin, M., Miyata, M., Ward, J.M., Lambert, G., and Gonzalez, F.J. (2000). Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis [In Process Citation]. Cell 102, 731-744.

  1. Chawla, A., Saez, E., and Evans, R.M. (2000). "Don't know much bile-ology" [In Process Citation]. Cell 103, 1-4.

2000-2001 Journal Club Schedule

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