Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 17, 2001
Room T-473 HSC

Speaker: Scott Auerbach
Topic: The Role of Nuclear Receptors FXR and LXR in Cholesterol Homeostasis

References:

  1. Goodwin, B., Jones, S.A., Price, R.R., Watson, M.A., McKee, D.D., Moore, L.B., Galardi, C., Wilson, J.G., Lewis, M.C., Roth, M.E., Maloney, P.R., Willson, T.M., and Kliewer, S.A. (2000). A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis [In Process Citation]. Mol. Cell 6, 517-526.

  2. Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.M., Hammer, R.E., and Mangelsdorf, D.J. (1998). Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93, 693-704.

  3. Repa, J.J., Turley, S.D., Lobaccaro, J.A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R.A., Dietschy, J.M., and Mangelsdorf, D.J. (2000). Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers [see comments]. Science 289, 1524-1529.

  4. Sinal, C.J., Tohkin, M., Miyata, M., Ward, J.M., Lambert, G., and Gonzalez, F.J. (2000). Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis [In Process Citation]. Cell 102, 731-744.

Reviews:
  1. Chawla, A., Saez, E., and Evans, R.M. (2000). "Don't know much bile-ology" [In Process Citation]. Cell 103, 1-4.


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