Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 3, 2001
Room T-473 HSC

Speaker: William A. Catterall
Topic: Just SNARE 'em: Reconstitution of Vesicle Fusion from Pure Proteins

References:

  1. Nickel, W., Weber, T., McNew, J.A., Parlati, F., Soellner, T.H. and Rothman, J.E. (1999) Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNARES and t-SNARES. Proc. Natl. Acad. Sci. USA 96: 12571-12576.

  2. Parlati, F., Weber, T., McNew, J.A., Westermann, B., Soellner, T.H. and Rothman, J.E. (1999) Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain. Proc. Natl. Acad. Sci. USA 96: 12565-12570.

  3. McNew, J.A., Weber, T., Engelman, D.M., Soellner, T.H. and Rothman, J.E. (1999) The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion. Mol. Cell 4: 415-421.

  4. McNew, J.A., Weber, T., Parlati, F., Johnston, R.J., Melia, T.J., Soellner, T.H. and Rothman, J.E. (2000) Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J. Cell Biol. 150: 105-117.

  5. Weber, T., Parlati, F., McNew, J.A., Johnston, R.J., Westermann, B., Soellner, T.H. and Rothman, J.E. (2000) SNAREpins are functionally resistant to disruption by NSF and alpha SNAP. J. Cell Biol. 149: 1063-1072.

  6. McNew, J.A., Parlati, F., Fukuda, R., Johnston, R.J., Paz, K., Paumet, F., Soellner, T.H. and Rothman, J.E. (2000) Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407: 153-159.

  7. Parlati, F., McNew, J.A., Fukuda, R., Miller, R., Soellner, T.H. and Rothman, J.E. (2000) Topological restriction of SNARE-dependent membrane fusion. Nature 407: 194-198.


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