Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 7, 2001
Room T-473 HSC

Speaker: Susan Hamilton
Topic: "Purging the Plaques"; Reductions in plaque burden and cognitive deficits by Aß immunization in mouse models of Alzheimers

References:

  1. Chen, G., et al. A learning deficit related to age and ß-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408, 975-979 (2000).

  2. Morgan, D., et al. Aß peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 40, 982-985 (2000).

  3. Janus, C., et al, Aß peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease. Nature 408, 979-982 (2000).

Background for Reference # 1:

Games, D., et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F ß-amyloid precursor protein. Nature 373, 523-527 (1995).

Schenk, D., et al., Immunization with amyloid-ß attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).

Bard, F., et al, Peripherally administered antibodies against amyoid ß-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med 6, 916-919 (2000).

Reviews:

Hardy, J. Amyloid, the presenillins and Alzheimer's disease. Tr Neurosc 20, 154-159 (1997).

Roses, A. Apolipoprotein E affects the rate of Alzheimer disease expression: ß-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J Neuropath Exp Neuro 53, 429-437 (1994).

Selkoe, D. J. Alzheimer's disease: a central role for amyloid. J Neuropath Exp Neuro 53, 438-447 (1994).

Selkoe, D. J. The cell biology of ß-amyloid precursor protein and presenilin in Alzheimer's disease. Tr Cell Bio 8, 447-453 (1998).

Van Leuven, F. Single and multiple transgenic mice as models for Alzheimer's disease. Prog Neurobio 61, 1305-312 (2000).


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