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Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 21, 2001
Room T-473 HSC

Speaker: Jennifer Fitzpatrick
Topic: SIR2: A Metabolic Sensor for Aging

References:

  1. Lin, S-J, Defossez, P-A., and Guarente, L. Requirement of NAD and SIR2 for life-span extension by calorie resetricion in Saccharomyces cerevisiae. Science 289: 2126-2128, 2000

  2. Imai, S. Armstrong, C.M., Kaeberlein, M., and Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent deacetylase. Nature 403: 795 2000

  3. Landry, J., Sutton, A., Tafrov, S.T., Heller, R.C., Stebbins, J., Pillus, L., and Sternglanz, R. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. PNAS 97: 5807-5811, 2000

  4. Smith, J.S., Brachmann, C.B., et al. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. PNAS 97: 6658-6663, 2000

  5. Sherman, J.M., Stone, E.M., Freeman-Cook, L.L., Brachman, C.B., Boeke, J.D., and Pillus, L. The Conserved Core of a Human SIR2 Homologue Functions in Yeast Silencing. Mol. Biol. Cell 10: 3045-3059, 1999

  6. Kaeberlein, M., McVey, M., and Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevesiae by two different mechanisms. Genes & Dev. 13: 2570-2580, 1999

  7. Weindruch, R., Walford, R.L., Fligiel, S., and Guthrie, D. The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake. J. Nutrition 116: 641-654, 1986

Reviews:
  1. Campisis, J. Aging, Chromatin, and Food Restriction--Connecting the Dots. Science 289: 2062, 2000

  2. Guarente, L. Sir2 links chromatin silencing, metabolism, and aging. Genes & Dev. 14: 1021-1026, 2000

  3. Shore, D. The Sir2 protein family: A novel deacetylase for gene silencing and more. PNAS 97: 14030-14032, 2000

  4. Guarente, L. Diverse and dynamic functions of the Sir silencing complex. Nature Genetics 23: 281-285, 1999


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