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Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, March 28, 2001
Room T-473 HSC

Speaker: Margaret Allen
Topic: Insulin release from ß -Cells: cAMP dependent, PKA dependent , PKA anchored and cAMP dependent, PKA independent mechanisms

References:

  1. Lester, L.B., M.C. Faux, J.B. Nauert & J.D. Scott. Targeted Protein Kinase A and PP-2B Regulated Insulin Secretion through Reversible Phosphorylation. Endocrinology 142(3):1218-1227 (2001)

  2. Lester, L.B., L.K. Langeberg & J.D. Scott. Anchoring of Protein Kinase A Facilitates Hormone-Mediated Insulin Secretion. Proc Natl Acad Sci USA 94:14942-14947 (1997).

  3. Fraser, I.D.C., S.J. Tavalin, L.B. Lester, L.K. Langeberg, A.M. Westphal, R.A. Dean, N.V. Marrion & J.D. Scott. A Novel Lipid-Anchored A-Kinase Anchoring Protein Facilitates cAMP-Responsive Membrane Events. EMBO J 17(8):2261-2272 (1998).

  4. Holz, G.G., C.A. Leech, R.S. Heller, M. Castonguay & J.F. Haebener. cAMP-dependent Mobilization of Intracellular Ca2+ Stores by Activaton of Ryanodine Receptors in Pancreatic ß -Cells. J Biol Chem 274(20):14147-14156 (1999).

  5. Bode, H., B. Moormannm, R. Dabew, & B. Göke. Glucagon-Like Peptide 1 Elevates cytosolic Calcium in Pancreatic ß -Cells Independently of Protein Kinase A. Endocrinology 140:3919-3927 (1999).

  6. Leech, C.A., G.G. Holz, O. Chepurny, & J.F. Habener. Expression of cAMP-Regulated Guanine Nucleotide Exchange Factors in Pancreatic ß -Cells. Biochem Biophysical Res Comm 278:44-47 (2000).

  7. Ozaki, N. T. Shibasaki, Y. Kashima, T. Miki, K. Takasashi, H. Ueno, Y. Sunaga, H. Yano, Y. Matsuura, T. Iwanaga, Y. Takai, & S. Seino. cAMP-GEFII is a Direct Target of cAMP in Regulated Exocytosis. Nature Cell Biology 2:805-811 (2000).

Reviews:
  1. Jones, P.M. and S.J. Persaud. Protein Kinases, Protein Phosphorylation, and the Regulation of Insulin Secretion from Pancreatic ß -Cells. Endocrine Reviews 19(4):429-461 (1998).


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