Current Topics in Pharmacology
12:30 PM, Wednesday, March 7, 2001
Room T-473 HSC
Speaker: Joe Beavo
Topic: Protease activated receptors: PAR for the course
Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem 2000 Aug 18;275(33):25216-21.
Trejo J, Coughlin SR. Related Articles The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem 1999 Jan 22;274(4):2216-24.
Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci USA 1998 Nov 10;95(23):13698-702.
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature 2000 Apr 6;404:609-13.
Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM, Reynolds EE, Oksenberg D. Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide. Mol Pharmacol 2000 Dec;58(6):1178-87.
Commentary Hollenberg MD. Receptor binding and agonist efficacy: new insights from mutants of the thrombin protease-activated receptor-1 (PAR-1). Mol Pharmacol 2000 Dec;58(6):1175-7.
O'Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ,Woulfe DS, Brass LF. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem 2000 May 5;275(18):13502-9.
Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000 Sep 14;407(6801):258-64.
2000-2001 Journal Club Schedule