Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 25, 2001
Room T-473 HSC

Speaker: Jennifer Glick
Topic: Ghrelin, the newest player in body weight regulation.

Reading List:

  1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656.

  2. Hosoda H., Kojima M., Matsuo H., and Kangawa K. (2000) Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J. Biol. Chem. 275:21995.

  3. Date Y., Murikami N., Kojima M., Kuroiwa T., Matsukura S., Kangawa K., and Nakazato M. (2000) Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem. Biophys. Res. Comm. 275:477.

  4. Tschop M., Smiley D.L., and Heiman M.L. (2000) Ghrelin induces adiposity in rodents. Nature 407:908.

  5. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., and Nakazato M. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinol 141:4255.

  6. Wren A.M., Small C.J., Ward H.L., Murphy K.G., Dakin C.L., Taheri S., Kennedy A.R., Roberts G.H., Morgan D.G.A., Ghatei M.A., and Bloom S.R. (2000) The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinol 141:4235.

  7. Gualillo O., Camino J.E., Blanco M., Garcia-Caballero T., Kojima M., Kangawa K., Dieguez C., Casanueva F.F. (2001) Ghrelin, a novel placental derived hormone. Endocrinol 142:788.

  8. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., and Matsukura S. (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194.

  9. Toshinai K., Mondal M.S., Nakazato M., Date Y., Murakami N., Kojima M., Kangawa K., and Masukura S. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem. Biophys. Res. Comm. 281:1220.

  10. Tschop M., Weyer C., Tataranni P.A., Devanarayan V., Ravussin E., and Heiman M.L. (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707.

Reviews:
  1. Waxman D.J. and Frank S.J. Growth Hormone Action. From Principles of Molecular Regulation (P.M. Conn and A.R. Means, eds.) Humana Press, Inc., Totowa NJ.

  2. Gaylinn B.D., Nass R., Toogood A.A., and Thorner, M.O. Growth Homone-Releasing Hormone and Growth Hormone Secretagogues: Basic Physiology and Clinical Implications. From Endocrinology, 4th ed. (L.J. DeGroot and J.L. Jameson, eds.) WB Saunders, Philadelphia PA.

  3. Kojima, M., Hosoda, H., Matsuo, H. and Kangawa, K. (2001) Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol. Metabol. 12:118.

  4. Folwaczny, C., Chang, J.K., and Tschop, M. (2001) Ghrelin and motilin: two sides of one coin? Eur. J. Endocrinol. 144:R1.


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