Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 9, 2001
Room T-473 HSC

Speaker: Ben Cheyette
Topic: Opposites attract...or repel...or both: Axon guidance through the looking glass (across the midline).

References:

  1. Stein E, Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 2001 Mar 9;291(5510):1928-38.

  2. Stein E, Zou Y, Poo M, Tessier-Lavigne M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 2001 Mar 9;291(5510):1976-82.

  3. Zou Y, Stoeckli E, Chen H, Tessier-Lavigne M. Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell 2000 Aug 4;102(3):363-75.

  4. Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 1999 Jun 25;97(7):927-41.

  5. Giger RJ, Kolodkin AL. Silencing the Siren. Guidance Cue Hierarchies at the CNS Midline. Cell 2001 Apr 6;105(1):1-4. (Mini Review)


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