Current Topics in Pharmacology
12:30 PM, Wednesday, October 24, 2001
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)
Speaker: Derek Wong
Topic: O-glycosylation: Do you want one lump or two in your signaling brew?
Gao, Y., Wells, L., Comer, F. I., Parker, G. J., and Hart, G. W. (2001). "Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain." J Biol Chem. 276, 9838-45.
Liu, K., Paterson, A. J., Chin, E., and Kudlow, J. E. (2000). "Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death." Proc Natl Acad Sci U S A 97, 2820-25.
Lubas, W. A., Frank, D. W., Krause, M., and Hanover, J. A. (1997). "O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats." J Biol Chem. 272, 9316-24.
Lubas, W. A., and Hanover, J. A. (2000). "Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity." J Biol Chem. 275, 10983-88.
Shafi, R., Iyer, S. P., Ellies, L. G., O'Donnell, N., Marek, K. W., Chui, D., Hart, G. W., and Marth, J. D. (2000). "The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny." Proc Natl Acad Sci U S A. 97, 5735-5739.
Comer, F. I., and Hart, G. W. (2000). "O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate." J Biol Chem. 275, 29179-82.
Hanover, J. A. (2001). "Glycan-dependent signaling: O-linked N-acetylglucosamine." Faseb J. 15, 1865-1876.
Wells, L., Vosseller, K., and Hart, G. W. (2001). "Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc." Science. 291, 2376-2378.
2001-2002 Journal Club Schedule