Current Topics in Pharmacology
12:30 PM, Wednesday, October 31, 2001
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)
Speaker: Anke Witting
Topic: Control of Trk Signaling by Membrane Trafficking
Saragovi HU, Zheng W, Maliartchouk S, DiGuliemo GM, Mawal YR, Kamen A, Woo
SA, Cuello AC, Debeir T and Neet KE. (1998) "A TrkA-selective, fast internalizing
nerv growth factor-antibody complex induces trophic but not neuritogenic
signals." J. Biol. Chem. 273(52): 34933-40.
Zhang Y, Moheban DB, Conway BR, Bhattacharyya A and Segal RS. (2000) "Cell surface
Trk receptors mediate NGF-induced survival while internalized receptors
regulate NGF-induced differentiation." J. Neurosci. 20:5671-78.
Kuruvilla R, Ye H and Ginty DD. (2000) "Spatially and functionally distinct roles of
the PI3-K effector pathway during NGF signaling in sympathetic neurons".
York RD, Molliver DC, Grewal SS, Stenberg PE, McCleskey EW and Stork PJS. (2000)
"Role of phosphoinositide 3-kinase and endocytosis in nerve growth
factor-induced extracellular signal-regulated kinase activation via Ras and
Rap1". Mol. Cell. Biol. 20:18069-83
Huang EJ and Reichardt LF. (2001) "Neurotrophins:roles in neuronal development and
function". Annu. Rev. Neurosci. 24:677-736
Patapoutian A and Reichardt LF. (2001) "Trk receptors:mediators of neurotrophin
action". Current Opinion in Neurobiology. 11:272-280
McPherson PS, Kay BK and Hussain NK. (2001) "Signaling on the endocytic pathway".
2001-2002 Journal Club Schedule