Pharmacology 514:
Current Topics in Pharmacology
Journal Club


Announcements

Schedule

Faculty

Instructions for
Speakers


JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 3, 2000
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Stan McKnight
Topic: Dicer: ruler and defender of the genome (an update on RNAi)

References:

  1. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000 Mar 31;101(1):25-33.

  2. Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 2001 Jan 18;409(6818):363-6.

  3. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001 May 24;411(6836):494-8.

  4. Aravin AA, Naumova NM, Tulin AV, Vagin VV, Rozovsky YM, Gvozdev VA. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr Biol. 2001 Jul 10;11(13):1017-27.

  5. Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science. 2001 Aug 10;293(5532):1146-50.

  6. Knight SW, Bass BL. A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans. Science. 2001 Sep 21;293(5538):2269-71.

  7. Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001 Aug 3;293(5531):834-8.

Reviews:
  1. Sharp PA. RNA interference--2001. Genes Dev. 2001 Mar 1;15(5):485-90.

  2. Matzke M, Matzke AJ, Kooter JM. RNA: guiding gene silencing. Science. 2001 Aug 10;293(5532):1080-3.


2001-2002 Journal Club Schedule
Other
Pharmacology
Courses

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives