Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 16, 2002
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Bill Catterall
Topic: Why not Na+? The Structural Basis for K+ Channel Selectivity

References:

  1. Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R.,: "The structure of the potassium channel: molecular basis of K+ conduction and selectivity" Science. 1998 280(5360):69-77.

  2. Roux B, MacKinnon R.: "The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations" Science 1999 285(5424):100-2.

  3. Jiang Y, MacKinnon R.: "The barium site in a potassium channel by x-ray crystallography". Gen. Physiol. 2000 115(3):269-72.

  4. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R.: "Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors" Nature 2001 411(6838):657-61.

  5. Morais-Cabral JH, Zhou Y, MacKinnon R.: "Energetic optimization of ion conduction rate by the K+ selectivity filter" Nature 2001 414(6859):37-42.

  6. Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R.: "Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution" Nature 2001 414(6859):43-8.


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