Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, March 6, 2002
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Sandra Bajjalieh
Topic: Anxious to know: The role of Corticotropin Releasing Factor in anxiety and the stress response

References:

  1. Muglia L, Jacobson L, Dikkes P, Majzoub JA.,"Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need" Nature. 1995 Feb 2;373(6513):427-32.

  2. Dunn AJ, Swiergiel AH., "Behavioral responses to stress are intact in CRF-deficient mice" Brain Res 1999 Oct 16;845(1):14-20.

  3. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W., "Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1" Nat Genet. 1998 Jun;19(2):162-6.

  4. Smith GW, Aubry JM, Dellu F, Contarino A, Bilezikjian LM, Gold LH, Chen R, Marchuk Y, Hauser C, Bentley CA, Sawchenko PE, Koob GF, Vale W, Lee KF, "Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development" Neuron 1998 Jun;20(6):1093-102.

  5. Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale W, Gold LH., "Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1" Brain Res 1999 Jul 17;835(1):1-9.

  6. Bale TL, Contarino A, Smith GW, Chan R, Gold LH, Sawchenko PE, Koob GF, Vale WW, Lee KF., "Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress" Nat Genet 2000 Apr;24(4):410-4.

  7. Kishimoto T, Radulovic J, Radulovic M, Lin CR, Schrick C, Hooshmand F, Hermanson O, Rosenfeld MG, Spiess J., "Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2" Nat Genet 2000 Apr;24(4):415-9.

  8. Coste SC, Kesterson RA, Heldwein KA, Stevens SL, Heard AD, Hollis JH, Murray SE, Hill JK, Pantely GA, Hohimer AR, Hatton DC, Phillips TJ, Finn DA, Low MJ, Rittenberg MB, Stenzel P, Stenzel-Poore MP., "Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2" Nat Genet 2000 Apr;24(4):403-9.

  9. Preil J, Muller MB, Gesing A, Reul JM, Sillaber I, van Gaalen MM, Landgrebe J, Holsboer F, Stenzel-Poore M, Wurst W., "Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2" Endocrinology 2001 Nov;142(11):4946-55.

  10. Bale TL, Picetti R, Contarino A, Koob GF, Vale WW, Lee KF., "Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior" J Neurosci 2002 Jan 1;22(1):193-9.

Reviews:
  1. Coste SC, Murray SE, Stenzel-Poore MP., "Animal models of CRH excess and CRH receptor deficiency display altered adaptations to Stress" Peptides Coste SC, Murray SE, Stenzel-Poore MP., Animal models of CRH excess and CRH receptor deficiency display altered adaptations to Stress, Peptides 2001 May;22(5):733-41.


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