Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 17, 2002
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Edith Wang
Topic: Ageing: The price of tumor suppression?

References:

  1. Kaeberlein, M., McVey, M., and Guarente, L; ". The SIR2/3/4 Complex and Sir2 Alone Promote Longevity in Saccharomyces Cerevisiae by Two Different Mechanisms. " Genes Dev. 1999; 13:2570-2580.

  2. Imai, S.-I., Armstrong, C.M., Kaeberlein, M., and Guarente, L.; "Transcriptional Silencing and Longevity Protein Sir2 is an NAD-Dependent Histone Deacetylase" Nature 2000; 403:795-800.

  3. Tissenbaum, H.A. and Guarente, L.; ". Increased Dosage of a Sir-2 Gene Extends Lifespan in Caenorhabditis elegans." Nature 2001; 410:227-230.

  4. Lin, S.J., Defossez, P.A., and Guarente, L.; "Requirement of NAD and SIR2 for life span extension by calorie restriction in Saccharomyces Cerevisiae" Science 2000 289:2126-2128.

  5. Luo, J., Nikolaev, A.Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W.; "Negative Control of p53 by Sir2a Promotes Cell Survival under Stress" Cell 2001 107:137-148.

  6. Vaziri, H., Dessain, S.K., Eaton, E.N., Imai, S.-I., Frye, R.A., Pandita, T.K., Guarente, L., and Weinberg, R.A.; "hSIR2/SIRT1 Functions as an NAD-Dependent p53 Deacetylase. " Cell 2001 107:149-159.

  7. Tyner, S.D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Park, S.H., Thompson, T., Karsenty, G., Bradley, A., and Donehower, L.A; ". p53 Mutant Mice that Display Early Ageing-Associated Phenotypes" Nature 2002 415:45-53.

Reviews:
  1. Tissenbaum, H.A. and Guarente, L.; "Model Organisms as a Guide to Mammalian Aging. " Dev. Cell 2002; 1: 9-19.

  2. Guarente, L., "Sir2 links Chromatin Silencing, Metabolism, and Aging. " Genes Dev. 2000; 14:1021-1026.


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