Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 1, 2002
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Neil Nathanson
Topic: Cycling through the nervous system with Cdk5: a plethora of effects at diverse developmental stages

References:

  1. Ohshima T, Ward JM, Huh CG, Longenecker G, Veeranna, Pant HC, Brady RO, Martin LJ, Kulkarni AB; "Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death." PNAS. 1996; Oct 1; 93(20): 11173-8.

  2. Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai LH; " Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality." Neuron 1997; Jan; 18(1): 29-42.

  3. Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH.; "p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment." J. Neurosci. 2001; Sep 1; 21(17): 6758-71.

  4. Tanaka T, Veeranna, Ohshima T, Rajan P, Amin ND, Cho A, Sreenath T, Pant HC, Brady RO, Kulkarni AB; "Neuronal cyclin-dependent kinase 5 activity is critical for survival." J Neurosci. 2001 Jan 15; 21(2): 550-8.

  5. Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC Jr, Nairn AC, Greengard P.; "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons." Nature 1999 Dec 9; 402(6762): 669-71.

  6. Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P.; "Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5." Nature 2001 Mar 15; 410(6826): 376-80.

  7. Fu AK, Fu WY, Cheung J, Tsim KW, Ip FC, Wang JH, Ip NY. ; "Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction." Nat. Neurosci. . 2001 Apr; 4(4): 374-81.

  8. Li BS, Zhang L, Takahashi S, Ma W, Jaffe H, Kulkarni AB, Pant HC.; "Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3." EMBO J. 2002 Feb 1; 21(3): 324-33.

  9. Tomizawa K, Ohta J, Matsushita M, Moriwaki A, Li ST, Takei K, Matsui H.; "Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity." J. Neurosci. 2002 Apr 1; 22(7): 2590-7.

  10. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH.; "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration." Nature . 1999 Dec 9; 402(6762): 615-22.

Reviews:
  1. Maris M, Sandmaier BM, Maloney DG, McSweeney PA, Woolfrey A, Chauncey T, Shizuru J, Niederwieser D, Blume KG, Forman S, Storb R.; "Non-myeloablative hematopoietic stem cell transplantation." Transfus Clin Biol. 2001; 8(3):231-40.

  2. Dhavan R, Tsai LH; "A decade of CDK5." Nat Rev Mol Cell Biol 2001 Oct; 2(10): 749-59.

  3. Paglini G, Caceres A; "The role of the Cdk5--p35 kinase in neuronal development." Eur J Biochem. 2001 Mar; 268(6): 1528-33.


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