Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 1, 2002
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Todd Scheuer
Topic: What A Long Strange TRP It's Been: Novel TRP Ion Channels Participating In Cold Sensing And Calcium Homeostasis

References:

  1. McKemy, D.D., Neuhausser, W.M., and Julius, D. ; "Identification of a cold receptor reveals a general role for TRP channels in thermosensation." Nature. 2002; 416: 52-58.

  2. Peier, A.M., Moqrich, A., Hergarden, A.C., Reeve, A.J., Andersson, D.A., Story, G.M., Earley, T.J., Dragoni, I., McIntyre, P., Bevan, S., and Patapoutian, A.; "). A TRP channel that senses cold stimuli and menthol." Cell 2002; 108: 705-15.

  3. Nadler, M.J., Hermosura, M.C., Inabe, K., Perraud, A.L., Zhu, Q., Stokes, A.J., Kurosaki, T., Kinet, J.P., Penner, R., Scharenberg, A.M., and Fleig, A.; "LTRPC7 is a Mg_ATP-regulated divalent cation channel required for cell viability." Nature 2001; 411: 590-95.

  4. Runnels, L.W., Yue, L., and Clapham, D.E.; "TRP-PLIK, a bifunctional protein with kinase and ion channel activities." Science 2001 291: 1043-47.

  5. Runnels, L.W., Yue, L., and Clapham, D.E.; "The TRPM7 channel is inactivated by PIP(2) hydrolysis." Nat Cell Biol 2002 4: 329-36.

Reviews:
  1. Maris M, Sandmaier BM, Maloney DG, McSweeney PA, Woolfrey A, Chauncey T, Shizuru J, Niederwieser D, Blume KG, Forman S, Storb R.; "Non-myeloablative hematopoietic stem cell transplantation." Transfus Clin Biol. 2001; 8(3):231-40.

  2. Clapham, D.E., Runnels, L.W., and Strubing, C.; "The TRP ion channel family." Nat Rev Neurosci 2001 2: 387-96.

  3. Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R.J., Bruford, E.A., Caterina, M.J., Clapham, D.E., Harteneck, C., Heller, S., Julius, D., Kojima, I., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A.M., Schultz, G., Shimizu, N., and Zhu, M.X. ; "A unified nomenclature for the superfamily of TRP cation channels." Mol. Cell 2002 9: 229-31.

  4. Clapham, D.E.; "Signal transduction. Hot and cold TRP ion channels." Science 2002 295: 2228-29.

  5. Zuker, C.S.; "Neurobiology: a cool ion channel." Nature 2002 416: 27-28.


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