Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 29, 2002
Room T-473 HSC
(NOTE: ROOM NUMBER HAS CHANGED FROM T-530/530A TO T-473)

Speaker: Kavita Shah
Topic: Till Death Do Us Part?? A Non-lethal Role for Death Receptors in Develoment

References:

  1. Srivatava AK et al.; "The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains." PNAS. 1997; 94: 13069-74.

  2. Pipsa J et al.; "Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF." Developmental Biology 1999; 216: 521-34.

  3. Tucker AS et al.; "Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis." Development 2000; 127: 4691-4700.

  4. Srivastava AK et al.; "Ectodysplasin-a1 is sufficient to rescue both hair growth and sweat glands in Tabby mice." Human Molecular Genetics 2001 19: 2973-81.

  5. Schmidt-Ulrich R et al.; "Requirement of NFkB/Rel for the development of hair follicles and other epidermal appendages." Development 2001 128: 3843-53.

  6. Doffinger R et al.; "X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NFkB signalling." Nature Genetics 2001 27: 277-85.

Reviews:
  1. Thesleff I, Mikkola M.; "Death receptor signaling giving life to ectodermal organs." Sciences STKE, www.stke.org/cgi/content/full/OC_sigtrans;2002/131/pe22 May 7, 2002.

  2. MacEwan DJ.; "TNF receptor subtype signaling: Differences and cellular consequences." Cellular Signaling 2002 14: 477-92.

  3. Budd R.; "Death Receptors couple to both cell proliferation and apoptosis." J. Clin. Investt. 2002 109: 437-42.


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