Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 2, 2002
Room T-473 HSC


Speaker: Dr. Stanley McKnight
Topic: Do you Guggul? Traditional Hindu medicine gives us a drug for hypercholesterolemia

References:

  1. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. May 31, 2002; 296(5573): 1703-6.

  2. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. September 3, 2002; 99(18): 11896-901.

  3. Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis". Cell. September 15, 2000; 102(6): 731-44.

  4. Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J Biol Chem. April 7, 2000; 275(14): 10638-47.

  5. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. Vitamin D receptor as an intestinal bile acid sensor. Science. May 17, 2002; 296(5571): 1313-6.

  6. Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J. The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol Endocrinol. September 2002; 16(9): 2065-76.

Reviews:

  1. Sinal C, Gonzalez F. Guggulsterone: an old approach to a new problem. Trends Endocrinol Metab. September 2002; 13(7): 275-6.

  2. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science. November 30, 2001; 294(5548): 1866-70.

  3. Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem. October 12, 2001; 276(41): 37735-8.

  4. Chawla A, Saez E, Evans RM. "Don't know much bile-ology". Cell. September 29, 2000; 103(1): 1-4.

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