Pharmacology 514:
Current Topics in Pharmacology
Journal Club

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, December 11, 2002
Room T-473 HSC


Speaker: Janet Lowe
Topic: Ravers Beware: MDMA Induced Neurotoxicity and the Role of Dopamine

References:

1. George A. Ricaurte, Jie Yuan, George Hatzidimitriou, Branden J. Cord, and Una D. McCann. Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"). Science. September 2002; 297(5590): 2260-2263.

2. A. Kanthasamy, J. E. Sprague, J. R. Shotwell, and D. E. Nichols. Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience. November 2002; 114(4): 917-924.

3. Jorge Camarero, Veronica Sanchez, Esther O'Shea, A. Richard Green, and M. Isabel Colardo. Studies, using in vivo microdialysis, on the effect of the dopamine uptake inhibitor GBR 12909 on 3,4-methylenedioxymethamphetamine (ecstasy)-induced dopamine release and free radical formation in the mouse striatum. Journal of Neurochemistry. June 2002; 81(5): 961-972.

4. Jie Yuan, Branden J. Cord, Una D. McCann, Brian T. Callahan, and George A. Ricaurte. Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity. Journal of Neurochemistry. March 2002; 80(6): 960-969.

1. J. E. Sprague, S. L. Everman, and D. E. Nichols. An Integrated Hypothesis for the serotonergic axonal loss induced by 3'4-methylenedioxymethamphetamine. Neurotoxicology. June 1998; 19(3): 427-41.

2. A. C. Parrott. Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity. Pharmacology, Biochemistry, and Behavior. April 2002; 71(4): 837-844.

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