Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 22, 2003
Room T-473 HSC

Speaker: Xi Chen
Topic: Think about longevity? Think IGF-1 Receptor.


  1. Martin Holzenberger, Joelle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Geloen, Patrick C. Even, Pascale Cervera, Yves Le Bouc. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. January 9, 2003; 421: 182-187.

  2. M. Tatar, A. Kopelman, D. Epstein, M.-P. Tu, C.-M. Yin, R. S. Garofalo. A mutant drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science. April 6, 2001; 292(5514): 107-110.

  3. David J. Clancy, David Gems, Lawrence G. Harshman, Sean Oldham, Hugo Stocker, Ernst Hafen, Sally J. Leevers, and Linda Partridge. Extension of life-span by loss of CHICO, a drosophila insulin receptor substrate protein. Science. April 6, 2001; 292(5514): 104-106.

  4. Catherine A. Wolkow, Koutarou D. Kimura, Ming-Sum Lee, and Gary Ruvkun. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. October 6, 2000; 290(5489): 147-150.

  5. Koutarou D. Kimura, Heidi A. Tissenbaum, Yanxia Liu, and Gary Ruvkun. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. August 15, 1997; 277(5328): 942-946.

  6. Enrica Migliaccio, Marco Giorgio, Simonetta Mele, Giuliana Pelicci, Paolo Reboldi, Pier Paolo Pandolfi, Luisa Lanfrancone, and Pier Giuseppe Pelicci. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. November 18, 1999; 402: 309-313.

  7. Andrzej Bartke, J. Chris Wright, Julie A. Mattison, Donald K. Ingram, Richard A. Miller, and George S. Roth. Longevity: Extending the lifespan of long-lived mice. Nature. November 22, 2001; 414(6862): 412.

  1. Christy S. Carter, Melinda M. Ramsey, and William E. Sonntag. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends in Genetics. June 1, 2002; 18(6): 295-301.

  2. David Gems and Linda Partridge. Insulin/IGF signalling and ageing: seeing the bigger picture. Current Opinion in Genetics & Development. June 1, 2001; 11(3): 287-292.

  3. Jun Nakae, Yoshiaki Kido, and Domenico Accili. Distinct and Overlapping Functions of Insulin and IGF-I Receptors. Endocrine Reviews. December 2001; 22(6): 818-835.

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