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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 5, 2003
Room T-473 HSC


Speaker: James Surapisitchat
Topic: Regulation of T-cell Signaling by Alternative Splicing of the Receptor-like Protein Tyrosine Phosphatase CD45

References:

  1. Kristen W. Lynch and Arthur Weiss. A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Molecular and Cellular Biology. January 2000; 20(1): 70-80.

  2. Gerdy B. ten Dam, Christian F. Zilch, Diana Wallace, Be Wieringa, Peter C. L. Beverley, Lambert G. Poels, and Gavin R. Screaton. Regulation of Alternative Splicing of CD45 by Antagonistic Effects of SR Protein Splicing Factors. Journal of Immunology. May 2000. 164(10): 5287-95.

  3. Huan-You Wang, Xiangdong Xu, Jian-Hua Ding, John R. Bermingham Jr., and Xiang-Dong Fu. SC35 plays a role in T cell development and alternative splicing of CD45. Molecular Cell. February 2001; 7(2): 331-42.

  4. Zheng Xu and Arthur Weiss. Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nature Immunology. 2002; 3(8): 764-71.

Reviews:
  1. Michelle L. Hermiston, Zheng Xu, Ravindra Majeti, and Arthur Weiss. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. The Journal of Clinical Investigation. 2002; 109(1): 9-14.

  2. Tom Maniatis and Bosiljka Tasic. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature. July 11, 2002; 418(6894): 236-43.

  3. Michelle L. Hermiston, Zheng Xu, and Arthur Weiss. CD45: A Critical Regulator of Signaling Thresholds in Immune Cells. Annual Review of Immunology. October 18, 2002; 21: 107-137


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