Current Topics in Pharmacology
12:30 PM, Wednesday, February 19, 2003
Room T-473 HSC
Speaker: Paul Muchowski
Topic: Bring Some Chips and Learn About CHIP: a U-box-containing E3 Ligase for Misfolded Proteins
Wanping Xu, Monica Marcu, Xitong Yuan, Edward Mimnaugh, Cam Patterson, and Len Neckers.
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu.
Proceedings of the National Academy of Sciences. October 1, 2002; 99(20): 12847-1285.
Yuzuru Imai, Mariko Soda, Shigetsugu Hatakeyama, Takumi Akagi, Tsutomu Hashikawa,
Kei-Ichi Nakayama, and Ryosuke Takahashi. CHIP is associated with Parkin, a Gene Responsible
for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity. Molecular
Cell. July 2002. 10(1): 55-67.
Simon Alberti, Jens Demand, Claudia Esser, Niels Emmerich, Hansjorg Schild, and Jorg
Hohfeld. Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of
chaperone substrates to the proteasome. Journal of Biological Chemistry. November 29,
2002; 277(48): 45920-45927.
Douglas Cyr, Jorg Hohfeld, and Cam Patterson. Protein quality control: U-box-containing
E3 ubiquitin ligases join the fold. Trends in Biochemical Sciences. July 2002; 27(7):
T. Wiederkehra, B. Bukaua, and A. Buchberger. Protein turnover: a CHIP programmed for
proteolysis. Current Biology. January 8, 2002; 12(1): R26-28.
2002-2003 Journal Club Schedule