Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 23, 2003
Room T-473 HSC


Speaker: Edith Wang
Topic: Unraveling Heterochromatin Formation and Gene Silencing

References:

  1. Ken-ichi Noma, C. David Allis, and Shiv I. S. Grewal. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science. August 10, 2001; 293(5532): 1150-1155.

  2. Barbara A. Boggs, Peter Cheung, Edith Heard, David L. Spector, A. Craig Chinault, and C. David Allis. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet. January 2002; 30(1): 73-76.

  3. Antoine H.F.M. Peters, Jacqueline E. Mermoud, Donal O'Carroll, Michaela Pagani, Dieter Schweizer, Neil Brockdorff, and Thomas Jenuwein. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet. January 2002; 30(1): 77-80.

  4. Yuhong Li, John R. Danzer, Pedro Alvarez, Andrew S. Belmont, and Lori L. Wallrath. Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Development. May 2003; 130(9): 1817-1824.

  5. Thomas A. Volpe, Catherine Kidner, Ira M. Hall, Grace Teng, Shiv I. S. Grewal, and Robert A. Martienssen. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. September 13, 2002; 297(5588): 1833-1837.

  6. Hall IM, Shankaranarayana GD, Noma K, Ayoub N, Cohen A, Grewal SI. Establishment and maintenance of a heterochromatin domain. Science September 27, 2002; 297(5590): 2232-2237.

Reviews:
  1. Eric J. Richards and Sarah C.R. Elgin. Epigenetic codes for heterochromatin formation and silencing: Rounding up the usual suspects. Cell. February 22, 2002; 108(4): 489-500.

  2. Niall Dillon and Richard Festenstein. Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet May 2002; 18(5): 252-8.

  3. Thomas Jenuwein. Molecular biology. An RNA-guided pathway for the epigenome. Science. September 27, 2002; 297(5590): 2215-8.


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