Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 7, 2004
Room T-473 HSC

Speaker: William Catterall
Topic: Anions Do It Differently: Structure, Function, and Genetic Diseases of Chloride Channels


    Articles on ClC Channel Structure

  1. Jentsch TJ, Steinmeyer K, Schwarz G. Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature. 1990 Dec 6; 348(6301): 510-4.

  2. Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 2002 Jan 17; 415(6869): 287-94.

  3. Dutzler R, Campbell EB, MacKinnon R. Gating the selectivity filter in ClC chloride channels. Science. 2003 Apr 4; 300(5616): 108-12.

  4. Estevez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron. 2003 Apr 10; 38(1): 47-59.

    Articles on Genetic Diseases of ClC Channels

  1. Steinmeyer K, Klocke R, Ortland C, Gronemeier M, Jockusch H, Grunder S, Jentsch TJ. Inactivation of muscle chloride channel by transposon insertion in myotonic mice. Nature. 1991 Nov 28; 354(6351): 304-8.

  2. Koch MC, Steinmeyer K, Lorenz C, Ricker K, Wolf F, Otto M, Zoll B, Lehmann-Horn F, Grzeschik KH, Jentsch TJ. The skeletal muscle chloride channel in dominant and recessive human myotonia. Science. 1992 Aug 7; 257(5071): 797-800.

  3. Lloyd SE, Pearce SH, Fisher SE, Steinmeyer K, Schwappach B, Scheinman SJ, Harding B, Bolino A, Devoto M, Goodyer P, Rigden SP, Wrong O, Jentsch TJ, Craig IW, Thakker RV. A common molecular basis for three inherited kidney stone diseases. Nature. 1996 Feb 1; 379(6564): 445-9.

  4. Kornak U, Kasper D, Bosl MR, Kaiser E, Schweizer M, Schulz A, Friedrich W, Delling G, Jentsch TJ. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell. 2001 Jan 26; 104(2): 205-15.


  1. George AL Jr, Bianchi L, Link EM, Vanoye CG. From stones to bones: the biology of ClC chloride channels. Curr Biol. 2001 Aug 7; 11(15): R620-8.

  2. Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr; 82(2): 503-68.

2003-2004 Journal Club Schedule

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