Current Topics in Pharmacology
12:30 PM, Wednesday, January 14, 2004
Room T-473 HSC
Speaker: Kristin Mahan
Topic: The Flip Side of Prions: How Translational Activator CPEB May Enhance Synaptic Plasticity Due to its Prion-like Properties.
Si K, Lindquist S, Kandel ER. A neuronal isoform of the aplysia CPEB has prion-like properties. Cell. 2003 Dec 26; 115(7): 879-91.
Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz AM, Miniaci MC, Kim JH, Zhu H, Kandel ER. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell. 2003 Dec 26; 115(7): 893-904.
Huang YS, Carson JH, Barbarese E, Richter JD. Facilitation of dendritic mRNA transport by CPEB. Genes Dev. 2003 Mar 1; 17(5): 638-53.
Mendez R, Richter JD. Translational control by CPEB: a means to the end. Nat Rev Mol Cell Biol. 2001 Jul; 2(7): 521-9.
Collinge J. Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci. 2001; 24: 519-50.
Roucou X, Gains M, LeBlanc AC. Neuroprotective functions of prion protein. J Neurosci Res. 2004 Jan 15; 75(2): 153-61.
Liu J, Schwartz JH. The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons. Brain Res. 2003 Jan 3; 959(1): 68-76.
2003-2004 Journal Club Schedule