Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 14, 2004
Room T-473 HSC


Speaker: Kristin Mahan
Topic: The Flip Side of Prions: How Translational Activator CPEB May Enhance Synaptic Plasticity Due to its Prion-like Properties.

References:

  1. Si K, Lindquist S, Kandel ER. A neuronal isoform of the aplysia CPEB has prion-like properties. Cell. 2003 Dec 26; 115(7): 879-91.

  2. Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz AM, Miniaci MC, Kim JH, Zhu H, Kandel ER. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell. 2003 Dec 26; 115(7): 893-904.

Reviews:

  1. Huang YS, Carson JH, Barbarese E, Richter JD. Facilitation of dendritic mRNA transport by CPEB. Genes Dev. 2003 Mar 1; 17(5): 638-53.

  2. Mendez R, Richter JD. Translational control by CPEB: a means to the end. Nat Rev Mol Cell Biol. 2001 Jul; 2(7): 521-9.

  3. Collinge J. Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci. 2001; 24: 519-50.

  4. Roucou X, Gains M, LeBlanc AC. Neuroprotective functions of prion protein. J Neurosci Res. 2004 Jan 15; 75(2): 153-61.

  5. Liu J, Schwartz JH. The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons. Brain Res. 2003 Jan 3; 959(1): 68-76.


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