Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 4, 2004
Room T-473 HSC

Speaker: Laura Beth Johnson
Topic: Prostaglandin Production in Gliomas: Enhancing Cancer Treatment with COX-2 Inhibitors


  1. Castilla EA, Prayson RA, Kanner AA, Rybicki LA, Tubbs RR, Vogelbaum MA, Barnett GH. Cyclooxygenase-2 in oligodendroglial neoplasms. Cancer. 2003 Oct 1; 98(7): 1465-72.

  2. Deininger MH, Meyermann R, Trautmann K, Morgalla M, Duffner F, Grote EH, Wickboldt J, Schluesener HJ. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Brain Res. 2000 Dec 1; 885(1): 111-6.

  3. Aas AT, Tonnessen TI, Brun A, Salford LG. Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. J Neurooncol. 1995; 24(2): 171-80.

  4. King JG Jr, Khalili K. Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. Oncogene. 2001 Oct 18; 20(47): 6864-70.

  5. Casper D, Lekhraj R, Yaparpalvi US, Pidel A, Jaggernauth WA, Werner P, Tribius S, Rowe JD, LaSala PA. Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. J Neurooncol. 2000; 46(3): 215-29.


  1. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001 Nov 30; 294(5548): 1871-5.

  2. Nathoo N, Barnett GH, Golubic M. The eicosanoid cascade: possible role in gliomas and meningiomas. J Clin Pathol. 2004 Jan; 57(1): 6-13.

  3. Choy H, Milas L. Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance? J Natl Cancer Inst. 2003 Oct 1; 95(19): 1440-52.

2003-2004 Journal Club Schedule

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