Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, March 10, 2004
Room T-473 HSC


Speaker: Janet Lowe
Topic: Psychotic Phosphatases: A Potential Role for Phosphatases and Their Inhibitors in Schizophrenia

References:

  1. Svenningsson P, Tzavara E.T, Carruthers R, Rachleff I, Wattler S, Nehls M, McKinzie D.L, Fienberg A.A, Nomikos G.C. and Greengard P. Diverse Psychotomimetics Act Through a Common Signaling Pathway. Science. 2004; 302: 1412-15.

  2. Albert KA, Hemmings HC Jr, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE Jr, Greengard P. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry. 2002 Aug; 59(8): 705-12.

  3. Miyakawa T, Leiter LM, Gerber DJ, Gainetdinov RR, Sotnikova TD, Zeng H, Caron MG, Tonegawa S. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15): 8987-92.

  4. Gerber DJ, Hall D, Miyakawa T, Demars S, Gogos JA, Karayiorgou M, Tonegawa S. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15): 8993-8.

Reviews:

  1. Greengard P, Allen PB, Nairn AC. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron. 1999 Jul; 23(3): 435-47.

  2. Fienberg AA, Greengard P. The DARPP-32 knockout mouse. Brain Res Brain Res Rev. 2000 Mar; 31(2-3): 313-9.

  3. Oliver CJ, Shenolikar S. Physiologic importance of protein phosphatase inhibitors. Front Biosci. 1998 Sep 1; 3: D961-72.

  4. Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science. 2002 Apr 26; 296(5568): 692-5.


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