Pharmacology 514:
Current Topics in Pharmacology
Journal Club


Announcements

Schedule

Faculty

Instructions for
Speakers


JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 5, 2004
Room T-473 HSC


Speaker: Neil Nathanson
Topic: When Good Factors Go BAD: NGF Kills Like a PRO

References:

  1. Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science. 2001 Nov 30; 294(5548): 1945-8.

  2. Naumann T, Casademunt E, Hollerbach E, Hofmann J, Dechant G, Frotscher M, Barde YA. Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons. J Neurosci. 2002 Apr 1; 22(7): 2409-18.

  3. Bhakar AL, Howell JL, Paul CE, Salehi AH, Becker EB, Said F, Bonni A, Barker PA. Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J Neurosci. 2003 Dec 10; 23(36): 11373-81.

  4. Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004 Feb 26; 427(6977): 843-8.

  5. Harrington AW, Leiner B, Blechschmitt C, Arevalo JC, Lee R, Morl K, Meyer M, Hempstead BL, Yoon SO, Giehl KM. From The Cover: Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16): 6226-30.

Reviews:

  1. Hempstead BL. The many faces of p75NTR. Curr Opin Neurobiol. 2002 Jun; 12(3): 260-7.

  2. Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci. 2003 Apr; 4(4): 299-309.

  3. Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci. 2004 Jan; 61(1): 35-48.


2003-2004 Journal Club Schedule
Other
Pharmacology
Courses

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives