Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 22, 2003
Room T-473 HSC

Speaker: Alexandra Few
Topic: NCS-1: a Sensitive Sensor of Calcium and its Role in Short-term Facilitation of Synaptic Transmission


  1. Sippy T, Cruz-Martin A, Jeromin A, Schweizer FE. Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1. Nat Neurosci. 2003 Oct; 6(10): 1031-1038.

  2. Tsujimoto T, Jeromin A, Saitoh N, Roder JC, Takahashi T. Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium currents at presynaptic nerve terminals. Science. 2002 Mar 22; 295(5563): 2276-9.

  3. Jackson MB, Redman SJ. Calcium dynamics, buffering, and buffer saturation in the boutons of dentate granule-cell axons in the hilus. J Neurosci. 2003 Mar 1; 23(5): 1612-21.

  4. Blatow M, Caputi A, Burnashev N, Monyer H, Rozov A. Ca2+ buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals. Neuron. 2003 Apr 10; 38(1):7 9-88.

  5. Felmy F, Neher E, Schneggenburger R. Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation. Neuron. 2003 Mar 6; 37(5): 801-11.

  6. Rozov A, Burnashev N, Sakmann B, Neher E. Transmitter release modulation by intracellular Ca2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics. J Physiol. 2001 Mar 15; 531(Pt 3): 807-26.

  7. Olafsson P, Wang T, Lu B. Molecular cloning and functional characterization of the Xenopus Ca(2+)-binding protein frequenin. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17): 8001-5.

  8. Atluri PP, Regehr WG. Determinants of the time course of facilitation at the granule cell to Purkinje cell synapse. J Neurosci. 1996 Sep 15; 16(18): 5661-71.


  1. Zucker RS. NCS-1 Stirs Somnolent Synapses. Nat Neurosci. 2003 Oct; 6(10): 1006-8.

  2. Zucker RS, Regehr WG. Short-term synaptic plasticity. Annu Rev Physiol. 2002; 64: 355-405.

  3. Zucker RS. Increased Ca2+ buffering enhances Ca2+-dependent process. J Physiol. 2001 Mar 15; 531(Pt 3): 583.

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