Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 29, 2003
Room T-473 HSC

Speaker: Seth Goldenberg
Topic: King of the PAK; Recent Advances in the Regultaion of Group II p21-activated Kinases (PAKs)


  1. Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct; 23(20): 7122-33.

  2. Ching YP, Leong VY, Wong CM, Kung HF. Identification of an autoinhibitory domain of p21-activated protein kinase 5. J Biol Chem. 2003 Sep 5; 278(36): 33621-4.


  1. Bagrodia S, Cerione RA. Pak to the future. Trends Cell Biol. 1999 Sep; 9(9): 350-5.

  2. Jaffer ZM, Chernoff J. p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol. 2002 Jul; 34(7): 713-7.

  3. Lian JP, Crossley L, Zhan Q, Huang R, Robinson D, Badwey JA. The P21-activated protein kinases (Paks) receive and integrate messages from a variety of signaling pathways. Adv Exp Med Biol. 2002; 507: 497-502.

  4. Li X, Minden A. Targeted disruption of the gene for the PAK5 kinase in mice. Mol Cell Biol. 2003 Oct; 23(20): 7134-42.

  5. Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi-Far R, Blagoev B, Mann M. Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene. 2002 May 30; 21(24): 3939-48.

  6. Yang F, Li X, Sharma M, Zarnegar M, Lim B, Sun Z. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem. 2001 May 4; 276(18): 15345-53.

2003-2004 Journal Club Schedule

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives