Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, December 10, 2003
Room T-473 HSC


Speaker: Charles Chavkin
Topic: How Far Have We Come in Understanding the Neurological Basis of Schizophrenia?

References:

    Genetic studies

    1. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002 Oct; 71(4): 877-92.

    2. Stefansson H, Thorgeirsson TE, Gulcher JR, Stefansson K. Neuregulin 1 in schizophrenia: out of Iceland. Mol Psychiatry. 2003 Jul; 8(7): 639-40.

    3. Klar AJ. Human handedness and scalp hair-whorl direction develop from a common genetic mechanism. Genetics. 2003 Sep; 165(1): 269-76.

    Gene array studies

    1. Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA. Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci. 2003 Jul 16; 23(15): 6315-26.

    2. Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron. 2000 Oct; 28(1): 53-67.

    Imaging studies

    1. Sommer I, Ramsey N, Kahn R, Aleman A, Bouma A. Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. Br J Psychiatry. 2001 Apr; 178: 344-51.

Reviews:

  1. Frankle WG, Lerma J, Laruelle M. The synaptic hypothesis of schizophrenia. Neuron. 2003 Jul 17; 39(2): 205-16.

  2. Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet. 2003 Feb 1; 361(9355): 417-9.

  3. Crow TJ. Schizophrenia as the price that homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Brain Res Brain Res Rev. 2000 Mar; 31(2-3): 118-29.


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