Current Topics in Pharmacology
12:30 PM, Wednesday, October 27, 2004
Room T-473 HSC
Speaker: Dan Morgan
Topic: The Neuroendocrine Precursor Goes Through Puberty: Growing Pains Associated with Pro-protein Maturation.
Christoph Westphal, Laurent Muller, An Zhou, Xiaorong Zhu, Susan Bonner-Weir, Morris Schambelan, Donald Steiner, Iris Lindberg, and Philip Leder. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell. 1999 March 5; 96(5): 689-700.
V Laurent, A Kimble, B Peng, P Zhu, JE Pintar, DF Steiner, and I Lindberg. Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion. Proc Natl Acad Sci U S A. 2002 March 5; 99(5): 3087-92.
Miroslav Sarac, Arthur Zieske, and Iris Lindberg. The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities. Endocrinology. 2002 June; 143(6): 2324-32.
2004-2005 Journal Club Schedule